Mohs micrographic surgery, or Mohs surgery, is a precise surgical technique in which the complete excision of skin cancer is checked by microscopic margin control. It offers the highest cure rates while maximizing preservation of healthy tissue. The principles behind it were developed by Dr. Frederic Mohs in the 1930s.

Mohs surgery is recognized as the treatment of choice for high risk basal cell carcinoma and squamous cell carcinoma. The skin cancer is progressively removed in stages. After each stage, the excision margins are microscopically examined for remaining cancer cells and this process is repeated until all cancer has been removed.